After losing her parents in a car accident, Okko goes to live with her grandmother, who runs a traditional Japanese inn built on top of an ancient spring said to have healing waters. Okko discovers there are spirits who live there that only she can see; not scary ones, but welcoming ghosts who keep her company and play games. The inn's motto is that it welcomes all and rejects none, and it is soon put to the test as a string of new guests challenge...

Inflicted with a deadly curse, a young warrior named Ashitaka sets out to the forests of the west in search of the cure that will save his life. Once there, he becomes inextricably entangled in a bitter battle that matches Lady Eboshi and a proud clan of humans against the forest's animal gods ... who are led by the brave Princess Mononoke, a young woman raised by wolves.